衰老解谜之密码有何用？
第19届世界老年学和老年医学大会将于2009年7月5日—7月9日在法国巴黎召开。大会的主题为长寿、健康、财富。来自世界各地的老年学和老年医学领域的专家学者将齐聚一堂，围绕生物学、健康学／老年医学、行为社会学、社会研究政策和实践四大领域展开讨论。并公布在各自领域内的最新研究成果，在世界范围内推广。这是世界老年学和老年医学领域的一件大事。
现将大会部分专题报告的内容简介如下，值得注意的是Hayflick 教授与Holliday教授都将组织论坛讨论介绍“衰老不再是生物学之谜”。尽管他们仍然面临“天下大乱”，并且不知“解谜之密码为何”“密码又有何用”。
1. GENETIC, EPIGENETIC AND POST-TRANSLATIONAL MECHANISMS OF AGING
Ladislas ROBERT, Hötel Dieu Hospital, Univ. Paris 5, France
Chairperson No. 1: Ladislas ROBERT
Chairperson No. 2: Jay Olshansky
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SPEAKER(S) |
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Ladislas Robert, France
Jay Olshansky, United States of America
Sylvie Ricard-Blum, France
Jacqueline Labat-Robert, France |
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TITLE(S) |
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L. ROBERT: INTRODUCTION, 5 MINUTES
SJ. OLSHANSKY: SCHOOL OF PUBLIC HEALTH, UNIVERSITY OF ILLINOIS AT CHICAGO "A BIODEMOGRAPHIC VIEW OF GENETIC MECHANISMS OF AGING"
S. RICARD-BLUM: UMR 5086 CNRS - UNIVERSITé LYON 1, 7 PASSAGE DU VERCORS, 69367 LYON CEDEX 07, FRANCE INTERACTION NETWORKS AS TOOLS TO INVESTIGATE THE MECHANISMS OF AGING.
L. ROBERT & J. LABAT-ROBERT: EPIGENETIC AND POST-TRANSLATIONAL MECHANISMS OF AGING. HôTEL-IEU, UNIV. PARIS V, FRANCE |
2. AGING AND ANTI-AGING NON INFLAMMATORY PROTEINS
ERIC BOULANGER, AGING BIOLOGY, France
Chairperson No. 1: Eric Boulanger
Chairperson No. 2: Kuro-o Makoto
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SPEAKER(S) |
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Maria ERIKSSON, Sweden
Luc BUEE, France
Eric BOULANGER, France
Makoto KURO-O, United States of America |
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TITLE(S) |
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A TRUNCATED LAMIN A PROTEIN IN THE PREMATURE AGING DISORDER HUTCHINSON-GILFORD PROGERIA SYNDROME. DR MARIA ERIKSSON, DEPARTMENT OF BIOSCIENCES AND NUTRITION, KAROLINSKA INSTITUTET, STOCKHOLM, SWEDEN.
IMPLICATION OF TAU IN NEUROFIBRILLARY DEGENERATION DURING AGING AND ALZHEIMER'S DISEASE DR LUC BUEE, INSERM U815, LILLE, FRANCE
PROTEIN GLYCATION IN AGING: ROLE AND CONTROL DR ERIC BOULANGER, AGING BIOLOGY, EA2693, MEDICAL SCHOOL,UNIVERSITY OF LILLE2, LILLE, FRANCE
THE ANTI-AGING MECHANISM MEDIATED BY KLOTHO PR MAKOTO KURO-O, UNIVERSITY OF TEXAS SOUTHWESTERN, DALLAS, USA |
3. TELOMERE DYNAMICS AND CARDIOVASCULAR AGING
Athanase Benetos, University of Nancy, France
Chairperson No. 1: Athanase Benetos
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SPEAKER(S) |
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Abraham AVIV, United States of America
Athanase BENETOS, France
Rosine NZIETCHUENG,
Isabelle GORENNE, United Kingdom |
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TITLE(S) |
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TELOMERE DYNAMICS AND EVALUATION OF CARDIAVASCULAR AGING : CLINICAL IMPLICATIONS
CLINICAL EVIDENCE FOR THE IMPLICATION OF TELOMERE LENGTH IN THE CARDIOVASCULAR AGING
TELOMERE LENGTH IN ATHEROGENIC AND NON ATHEROGENIC TISSUS
ENDOTHELIAL CELL SENESCENCE AND TELOMERE ATTRITION |
4. IMMUNOSENESCENCE: STATE OF THE ART
Tamas Fulop, Université de Sherbrooke, Canada
Chairperson No. 1: Tamas Fulop
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SPEAKER(S) |
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Tamas Fulop, Canada
Graham Pawelec, Germany
Michael P. Cancro, United States of America
Claudio Franceschi, Italy |
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TITLE(S) |
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T. FULOP: THE INNATE IMMUNE RESPONSE AND AGING
G. PAWELEC: CHRONIC VIRAL INFECTION AS A DRIVING FORCE FOR T CELLS IMMUNOSENESCENCE
M. CANCRO: B CELL CONTRIBUTION TO IMMUNOSENESCENCE
C. FRANCESCHI: INFLAMAGING: A UNIFYING THEORY FOR IMMUNOSENESCENCE |
5. NONCODING RNA AND EPIGENETIC CONTROL OF AGING: FROM WORM TO MAN
Eugenia Wang, University of Louisville, United States of America
Chairperson No. 1: Eugenia Wang
Chairperson No. 2: Anna McCormick
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SPEAKER(S) |
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Monica Driscoll, United States of America
Hyman Schipper, Canada
Weixiong Zhang, United States of America
Eugenia Wang, United States of America |
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MONICA DRISCOLL: MICRORNA MODULATION OF C. ELEGANS HEALTHSPAN AND LIFESPAN
EUGENIA WANG: PROGRAMMED MICRORNA SHIFT DURING MID-LIFE: THE START OF AGING FRAILTY
HYMAN SCHIPPER: MICRORNA PROFILING IN ALZHEIMERS DISEASE
WEIXIONG ZHANG: TRANSCRIPTIONAL REGULATION OF MICRORNA IN AGING BRAIN AND SENESCENT FIBROBLASTS |
6. MELATONIN, BIORHYTHMES AND AGING
Vladimir Anisimov, N.N.Petrov Research Institute of Oncology, Russian Federation
Chairperson No. 1: Vladimir Anisimov
Chairperson No. 2: Yvan Touitou
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SPEAKER(S) |
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Vladimir Anisimov, Russian Federation
Yvan Touitou, France
Ettore Ferrari, Italy |
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TITLE(S) |
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MELATONIN AS GEROPROTECTOR AND ANTICARCINOGEN
MELATONIN AND BIORHYRHMS IN NORMAL AND ACCELERATED AGING
MELATONIN SECRETION IN PHYSIOLOGICAL AGING, IN SENILE DEMENTIA AND IN CLINICALLY HEALTHY CENTENARIANS. |
7. MOLECULAR MECHANISMS OF BRAIN AGING AND AGE-RELATED NEURODEGENERATION: GENETICS, SIGNALING, CYTOSKELETAL ABNORMALITY, AND PROTEIN TOXICITY
Nozomu Mori, Nagasaki University School of Medicine, Japan
Chairperson No. 1: Nozomu Mori
Chairperson No. 2: Mahendra Thakur
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SPEAKER(S) |
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Nozomu Mori, Japan
Frederic Saudou, France
Yong-Sun Kim, Korea, Republic of
Mahendra Thakur, India |
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TITLE(S) |
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MAHENDRA THAKUR NEUROPROTECTIVE SIGNALING IN BRAIN AGING
NOZOMU MORI TUBULIN DEACETYLASES IN NEURONAL AGING IN VITRO AND IN VIVO
FREDERIC SAUDOU HUNTINGTON DISEASE: HUNTINGTIN AND THE CONTROL OF AXONAL TRANSPORT
YONG-SUN KIM MOLECULAR ETIOLOGIES UNDERLYING PRION DISEASE IN DROSOPHILA MODEL |
8. ESSENTIAL TRACE ELEMENT (ZN, CR, SE) DEFICIENCIES IN ELDERLY: WHICH POLICY OF SUPPLEMENTATION?? SYMPOSIUM ORGANISED BY SFERETE(FRENCH SOCIETY FOR TRACE ELEMENT RESEARCH) AND TEU(TRACE ELEMENT INSTITUTE FOR UNESCO/LYON
Anne-Marie Roussel, Universite Joseph Fourier, France
Chairperson No. 1: Monique Ferry
Chairperson No. 2: Guy Chazot
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SPEAKER(S) |
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Anne-Marie Roussel, France
Margaret Rayman, United Kingdom
Richard Anderson, United States of America
Monique Ferry, France
Guy Chazot, France |
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SELENIUM AS AN ANTI AGEING NUTRIENT MARGARET P RAYMAN, DIVISION OF NUTRITIONAL SCIENCES, FACULTY OF HEALTH AND MEDICAL SCIENCES, UNIVERSITY OF SURREY, GUILDFORD, GU2 7XH, UK
CHROMIUM AND AGING RICHARD A. ANDERSON DIET, GENOMICS AND IMMUNOLOGY LABORATORY, BELTSVILLE HUMAN NUTRITION RESEARCH CENTER, BELTSVILLE, MD20705.
ZINC SUPPLEMENTATION IN ELDERLY PEOPLE: BENEFITS AND LIMITS ANNE-MARIE ROUSSEL, LBFA/INSERM884, UNIVERSITY JOSEPH FOURIER, GRENOBLE, F38041
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9. AGEING BONE AND GENETICS
Serge FERRARI, Service des maladies osseuses, Switzerland
Chairperson No. 1: SERGE FERRARI
Chairperson No. 2: RENE RIZZOLI
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SPEAKER(S) |
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Douglas P. Kiel, United States of America
Serge Ferrari, Switzerland
Luigi Gennari, Italy |
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TITLE(S) |
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D KIEL: GENE-ENVIRONMENT INTERACTIONS ON THE AGEING SKELETON
L GENNARI: GENETICS OF MALE OSTEOPOROSIS
S FERRARI: PLEIOTROPIC EFFECTS OF OSTEOPOROSIS GENES ON AGE-RELATED DISORDERS |
10. AGEING IS NO LONGER AN UNSOLVED BIOLOGICAL PROBLEM
Leonard Hayflick, University of California, San Francisco, United States
Chairperson No. 1: Leonard Hayflick
Chairperson No. 2: Robin Holliday
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SPEAKER(S) |
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Leonard Hayflick, United States of America
Robin Holliday, Australia
Thomas Kirkwood, United Kingdom
Steven Austad, United States of America |
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TITLE(S) |
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THE CAUSES OF BIOLOGICAL AGEING ARE KNOWN (LEONARD HAYFLICK, UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, USA)
UNDERSTANDING THE BIOLOGICAL REASONS FOR AGEING (ROBIN HOLLIDAY, THE AUSTRALIAN ACADEMY OF SCIENCE, CANBERRA, AUSTRALIA)
AGEING IS SOLVED BUT ITS SOLUTION ALSO HIGHLIGHTS ITS COMPLEXITY - GEARING UP FOR THE CHALLENGES AHEAD (TOM KIRKWOOD, NEWCASTLE UNIVERSITY, NEWCASTLE UPON TYNE, UK)
MAKING SENSE (AND MAKING USE) OF PATTERNS OF MAMMALIAN LONGEVITY (STEVEN N. AUSTAD, UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER SAN ANTONIO, SAN ANTONIO, TEXAS, USA) |
11. NUTRITION AND BRAIN AGING: PRIMING THE BRAIN AGAINST THE RAVAGES OF TIME
James Joseph, USDA Human Nutrition Research Center on Aging at Tufts University, United States
Chairperson No. 1: James Joseph
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SPEAKER(S) |
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James Joseph, United States of America
Charles Ramassamy, Canada
Elizabeth Head, United States of America
Donald Ingram, United States of America |
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TITLE(S) |
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QUENCHING THE "FIRES" OF BRAIN AGING VIA NUTRITIONAL SUPPLEMENTATION WITH FRUITS AND WALNUTS
BENEFICIAL EFFECTS OF POLYPHENOLS FROM FOODS DURING AGEING AND IN ALZHEIMER’S DISEASE.
THE ROLE OF ANTIOXIDANT DIETS IN COGNITION IN THE AGED BEAGLE
DIET RESTRICTION VS CALORIC RESTRICTION MIMETICS IN BRAIN AGING AND DISEASES ASSOCIATED WITH BRAIN AGING |
12. WHY WE AGE: THE MODERN SYNTHESIS
Robin Holliday, The Australian Academy of Science, Australia
Chairperson No. 1: Robin Holliday
Chairperson No. 2: Leonard Hayflick
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SPEAKER(S) |
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Bruce Carnes, United States of America
S. Rattan, Denmark
Jay Olshansky, United States of America |
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TITLE(S) |
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WHY WE AGE ?: AN INTEGRATION OF CONCEPTS ACROSS BIOLOGICAL DISCIPLINES
MOLECULAR DAMAGE AND HETEROGENEITY DURING AGEING: ITS RELEVANCE AND CONSEQUENCE RATTAN, S.I.S LABORATORY OF CELLULAR AGEING, DEPARTMENT OF MOLECULAR BIOLOGY, AARHUS UNIVERSITY, GUSTAV WIEDS VEJ 10C; DK8000 AARHUS-C, DENMARK. EMAIL: RATTAN@MB.AU.DK AGEING AT THE MOLECULAR LEVEL IS CHARACTERIZED BY THE PROGRESSIVE ACCUMULATION OF MOLECULAR DAMAGE IN NUCLEIC ACIDS, PROTEINS, LIPIDS AND CARBOHYDRATES. THE MAIN SOURCES OF DAMAGE ARE ENVIRONMENTAL AND METABOLICALLY GENERATED FREE RADICALS, SPONTANEOUS ERRORS IN BIOCHEMICAL REACTIONS, AND VARIOUS NUTRITIONAL COMPONENTS, SUCH AS GLUCOSE. ALTHOUGH THE ACTION OF THE DAMAGING AGENTS IS MAINLY STOCHASTIC, THE RESULT, WHETHER A SPECIFIC MACROMOLECULE WILL BECOME DAMAGED AND WHETHER A DAMAGE CAN PERSIST, DEPEND ON THE STRUCTURE, LOCALISATION AND INTERACTIONS OF THE MACROMOLECULE WITH OTHER MACROMOLECULES, AND ON THE ACTIVITY AND EFFICIENCY OF A COMPLEX SERIES OF MAINTENANCE AND REPAIR SYSTEMS (MARS). THE RESULTING INCREASE IN MOLECULAR HETEROGENEITY HAS TWO MAJOR CONSEQUENCES IN TERMS OF INTERRUPTED NETWORKS AND ILLEGITIMATE NETWORKS. MORE SPECIFICALLY, DAMAGE IN MARS LEADS TO AGE-RELATED FAILURE OF HOMEODYNAMICS, ALTERED CELLULAR FUNCTIONING, REDUCED STRESS TOLERANCE, EMERGENCE OF DISEASES AND ULTIMATE DEATH. STRATEGIES FOR TESTING AND DEVELOPING EFFECTIVE MEANS OF INTERVENTION, PREVENTION AND MODULATION OF AGEING INCORPORATE MEANS TO MINIMIZE THE OCCURRENCE AND ACCUMULATION OF MOLECULAR DAMAGE, TO REDUCE MOLECULAR HETEROGENEITY, AND TO EVALUATE THE RELEVANCE OF THE TYPE AND EXTENT OF DAMAGE WITH RESPECT TO ITS ROLE IN AGEING AND AGE-RELATED DISEASES. SYSTEMS BIOLOGY APPROACH AND BIOINFORMATIC TOOLS COMBINED WITH NOVEL EXPERIMENTAL INTERVENTIONS ARE NECESSARY FOR THIS PURPOSE. MOLECULAR DAMAGE AND HETEROGENEITY DURING AGEING: ITS RELEVAMCE AND CONSEQUENCE
WHY WE AGE: A BIODEMOGRAPHIC PERSPECTIVE |
